Polynucleotide (PN) skin rejuvenation treatment is an advanced, doctor-administered injectable therapy designed to repair damaged skin, promote cellular renewal, and improve overall skin quality.
Popularly known as the “salmon DNA treatment” or “婴儿针” in Korea, this regenerative procedure uses bioactive molecules derived from salmon DNA (Polynucleotide) to stimulate collagen production, enhance skin elasticity, and restore a radiant, youthful complexion. Widely sought after for its ability to address fine lines, acne scars, enlarged pores, and dull skin, PN therapy is a key part of anti-ageing skincare in Singapore.
Polynucleotide (PN) therapy is a regenerative injectable treatment that uses ultra-purified DNA fragments derived from salmon to activate the skin’s natural healing processes. These polynucleotides are biocompatible molecules known for their ability to stimulate cellular repair, enhance microcirculation, and support collagen and elastin production.
Unlike traditional hyaluronic acid (HA) skinboosters that focus primarily on hydration, PN therapy targets the skin’s deeper biological functions. It promotes tissue regeneration, reduces inflammation, and improves the skin’s structural integrity—making it especially suitable for individuals struggling with acne scars, dullness, fine lines, and early signs of ageing.
This biologically active treatment is often referred to by its Korean nickname, “婴儿针,” which translates to “baby skin injection,” due to its ability to restore a soft, smooth, and radiant skin texture.
Polynucleotide (PN) therapy is a versatile skin rejuvenation treatment that targets a wide range of common aesthetic concerns. Thanks to its ability to stimulate tissue repair and collagen regeneration, PN injections are commonly used to treat:
Many patients refer to this multi-purpose injectable as a “collagen healing shot” due to its restorative properties across various skin types and conditions.
PN therapy works by delivering a concentrated dose of bioactive polynucleotides directly into the dermis using fine microinjections. These polynucleotides are extracted from salmon DNA, a natural source known for its high biocompatibility and regenerative potential.
Once injected, the PN molecules act on multiple levels:
The result is healthier, stronger, and more youthful-looking skin that continues to improve over the weeks following treatment. Some patients describe this rejuvenating process as “skin rebirth”—another reason why it’s often referred to as the “baby skin injection.”
Polynucleotide (PN) injectables come in multiple formulations, each designed to target specific skin concerns. While all variants are based on highly purified salmon DNA, their concentrations and compositions differ to suit various treatment goals. Many patients also refer to them by their box colours or nicknames, which are commonly used in aesthetic clinics across Singapore.
Often called the “black box” or “PN healer,” this is the classic and most established PN formulation. It is widely used to promote overall skin healing, boost collagen production, and improve skin radiance. Most suitable for patients with dull skin, early fine lines, and general skin ageing, this injectable is commonly referred to as “婴儿针” or the “baby skin injection” due to its ability to restore smoothness, firmness, and youthful glow.
Learn more about PN Healer here
Nicknamed the “blue box” version, this PN formulation is tailored for treating acne scars and rough skin texture. It contains a higher concentration of polynucleotides for enhanced dermal regeneration and scar remodeling. Precision manual injections are often used to place it directly beneath atrophic scars, helping to lift and smooth the skin over time.
For optimal outcomes, Dr Edwin frequently combines this treatment with subcision—a minor in-clinic procedure that helps release tethered scar bands under the skin. This dual approach allows the polynucleotides to work more effectively by promoting healing in a loosened, more mobile tissue plane.
Learn more about Subcision here
This gentle PN formulation—often called the “white box” version—is specially designed for the thin and delicate skin under the eyes. It works by strengthening and improving skin quality in the tear trough area, helping to reduce fine lines, smooth crepey texture, and lighten dark eye circles. By improving skin resilience and structure, this treatment is ideal for patients who want to refresh tired-looking eyes without using dermal fillers.
For patients concerned about dynamic wrinkles or crow’s feet around the eyes, Dr Edwin often recommends combining PN Eye with botulinum toxin injections. This helps to relax the overactive eye area muscles, allowing the skin to smooth out more effectively while the PN formulation works to restore skin thickness and quality.
Learn more about Botulinum Toxin here
Commonly known as the “pink box” or hydroboost variant, this formulation combines polynucleotides with hyaluronic acid. It is suitable for patients with dehydrated or sensitised skin, providing both regenerative repair and deep, long-lasting hydration. This dual-action injectable is frequently used after laser treatments or during seasonal skin recovery periods to restore the skin barrier and achieve a plump, glowing finish.
Combining polynucleotide (PN) injectables with hyaluronic acid (HA) skinboosters is a well-established approach to improve both skin structure and hydration. This synergistic treatment protocol leverages the collagen-stimulating properties of PN with the deep hydration benefits of stabilised HA—creating comprehensive skin rejuvenation from within.
The PN injectable (commonly known as the “black box” or “婴儿针”) works by repairing damaged skin and activating collagen production, while HA skinboosters—such as those formulated with NASHA™ technology—enhance skin moisture retention, improve elasticity, and deliver a smooth, supple glow.
Together, this combination offers multi-layered skin revitalisation that is greater than the sum of its parts.
Key Benefits of the PN + HA Skinbooster Combination:
This protocol is especially effective for individuals with dehydrated, dull, or ageing skin who are looking to restore both skin health and glow. It is commonly performed in alternating sessions or layered treatments depending on your skin needs.
Learn more about HA Skinboosters here
At our clinic, every PN treatment is tailored to your skin type, concern, and comfort level. Whether you are targeting full-face rejuvenation, acne scars, or the under-eye area, the procedure is performed with precision and care to ensure optimal results and minimal downtime.
Initial Consultation and Assessment
Your journey begins with a personalised consultation. Dr Edwin will assess your skin quality, treatment goals, and areas of concern before recommending the most suitable PN formulation—be it the classic black box version, scar-focused blue box, or the specialised white or pink variants. You’ll also discuss whether manual injection or device-assisted delivery is most appropriate for your needs.
Injection Technique: Manual vs Dermashine
PN injections can be administered using two main methods:
Dr Edwin may use a combination of both methods during your session, depending on the area being treated.
Comfort Measures and Post-Treatment Care
A topical numbing cream is applied before treatment to enhance comfort. Most patients report only mild pricks or pressure during the injections. After the procedure, temporary redness, mild swelling, or small injection marks may be visible for 1–3 days. Post-care instructions and a recovery cream will be provided to support healing and maximise results.
Repeat sessions may be recommended every 3–4 weeks for optimal skin repair and long-term collagen stimulation. Results continue to improve gradually over time as the skin regenerates.
Polynucleotide (PN) treatments are designed to work gradually by stimulating your skin’s natural healing and regeneration processes. Unlike filler-based treatments that offer immediate volume, PN therapy provides subtle and progressive improvements in skin quality, texture, and resilience.
When Will I See Results?
Most patients begin to notice visible improvements in skin smoothness, hydration, and glow within 2 to 3 weeks after their first session. However, because collagen stimulation and tissue repair take time, the most significant changes—such as improved elasticity, softened scars, and reduction in fine lines—are usually seen after a series of 3 to 4 sessions spaced 3 to 4 weeks apart.
How Long Do the Effects Last?
Results typically last 4 to 6 months, with ongoing collagen synthesis and skin strengthening continuing even after the treatment course is completed. Maintenance sessions every 4 to 6 months are recommended to prolong the effects and keep the skin in its best condition.
What Type of Improvements Can I Expect?
PN injectables are often described by patients as a “reset” for their skin—helping them achieve a youthful, healthy complexion without changing their natural facial contours.
To find the best PN clinic in Singapore, look for a medical aesthetic clinic with proven experience in administering polynucleotide treatments. The clinic should offer a range of PN formulations tailored for different skin concerns—such as general rejuvenation, acne scars, or under-eye wrinkles—and provide clear explanations during consultation. A qualified doctor should assess your skin and recommend a customised treatment plan to ensure safe, effective, and natural-looking results.
