
Due to Health Sciences Authority (HSA) advertising regulations, we are unable to mention the specific brand name of our polynucleotide treatment. However, we use a popular, premium polynucleotide formulation from Korea, widely associated online—and commonly referred to on social media—as "salmon sperm" or "salmon DNA." This treatment effectively rejuvenates the delicate eye area by reducing dark circles, smoothing fine lines, and enhancing overall skin hydration and elasticity.
Polynucleotide-based eye treatments are designed to stimulate collagen production, improving skin quality and elasticity around the eyes. They are formulated to target the delicate under-eye area, addressing concerns like fine lines, wrinkles, and reduced firmness.
These treatments are minimally invasive and provide a straightforward approach to under-eye rejuvenation with minimal downtime and discomfort. Polynucleotide eye treatments involve the use of purified DNA fragments called polynucleotides, derived from natural sources like salmon DNA.
These biocompatible molecules stimulate collagen production, promote skin repair, and improve overall skin texture. Polynucleotides are recognized for their ability to rejuvenate thin and sensitive skin, making them suitable for the delicate under-eye area.
This combination of benefits makes polynucleotide eye treatments effective for addressing concerns like fine lines, wrinkles, skin laxity, and reduced hydration in the under-eye area.
Polynucleotide eye treatments address various under-eye concerns, improving skin quality and providing a refreshed appearance:

Polynucleotide eye collagen stimulation treatments are minimally invasive procedures designed to improve under-eye skin quality, elasticity, and hydration. In Singapore, two methods are commonly used for administering these treatments: microneedle injections and the Dermashine injector gun. Both methods ensure precise delivery of polynucleotides to rejuvenate the delicate under-eye area.
Before starting the procedure, a numbing cream is applied to the under-eye area for approximately 30 minutes to reduce discomfort during the treatment. This step ensures that patients experience minimal pain, regardless of the method used.
The depth of the injections can be accurately controlled, allowing the treatment to target the optimal layer of skin for collagen stimulation and repair. Additionally, the device incorporates a vacuum suction mechanism that gently pulls the skin closer to the needles. This feature enhances precision and minimizes discomfort during the procedure.
Advantages of the Dermashine Injector Gun:
Redness or swelling is usually mild and resolves within a few days. Bruising, though rare, may occur and typically fades within 3-5 days. Most individuals can resume regular activities shortly after the treatment.

To achieve optimal results, 3 to 4 treatment sessions spaced 4 weeks apart are recommended. Maintenance sessions every 6 to 9 months help sustain the effects of collagen stimulation and keep the under-eye area rejuvenated and refreshed.
Polynucleotide eye collagen stimulation treatments are generally safe and well-tolerated when performed by experienced doctors in a clinical setting. These treatments use biocompatible, naturally derived materials, minimizing the risk of adverse reactions. However, as with any injectable treatment, there are some potential side effects and risks.
Polynucleotide eye treatments use highly purified DNA fragments derived from salmon. While the purification process removes most allergens, it is essential to inform your doctor of any seafood allergies during your consultation. Additional precautions, such as a patch test, may be taken to ensure the treatment is safe for you.
Results from polynucleotide eye treatments typically last 6 to 9 months. Factors like skin condition, age, and lifestyle can affect longevity. Maintenance sessions every 6 to 9 months are recommended to sustain collagen stimulation and keep the under-eye area rejuvenated.
Most patients experience minimal discomfort during the procedure. Numbing cream is applied beforehand to reduce any pain. The Dermashine injector gun, which uses tiny needles and controlled depth, ensures precise and comfortable treatment with minimal pain.
Polynucleotide treatments improve skin quality by stimulating collagen production and repairing damaged tissue. Unlike dermal fillers or botulinum toxin injections, these treatments address fine lines, reduced elasticity, and hydration from within, offering a natural approach to under-eye rejuvenation.
Yes, polynucleotide treatments can be combined with other aesthetic procedures, such as:
- Laser therapy Botulinum toxin injections
- Dermal fillers
Consult with your doctor to create a personalized treatment plan for comprehensive under-eye rejuvenation.
- Initial results in skin texture and hydration are noticeable within 1-2 weeks.
- Collagen stimulation and skin repair progress over several weeks, with the best results typically visible around 4-6 weeks after the procedure.
These treatments are suitable for individuals with:
- Fine lines or wrinkles around the eyes
- Reduced skin elasticity or firmness
- Dark circles caused by thin or poor-quality skin
- Dehydrated or dull under-eye skin
Consult with an experienced doctor in Singapore to determine if this treatment aligns with your needs.
To reduce the risk of bruising or irritation, patients are advised to:
- Avoid alcohol, aspirin, or blood-thinning medications for at least 48 hours before the procedure (unless otherwise directed by your doctor)
- Refrain from using active skincare ingredients like retinol or AHAs on the treatment area for a few days before the procedure
Post-treatment care is simple but important for optimal results:
- Avoid applying makeup to the treated area for 24 hours
- Refrain from strenuous activities, saunas, or hot baths for 24 hours
- Follow all aftercare instructions provided by your clinic
