Rejuran Healer | Anti-aging Collagen Stimulation Treatment

What Is Polynucleotide (PN) Skin Rejuvenation Therapy?

Polynucleotide (PN) Skin Rejuvenation Therapy is an advanced injectable treatment designed to revitalise the skin through natural healing, regeneration, and DNA repair processes. It uses purified DNA fragments derived from salmon to stimulate fibroblast activity, boost collagen production, and enhance skin hydration — helping to improve skin quality from within.

Due to Health Sciences Authority (HSA) advertising regulations in Singapore, we are unable to mention specific brand names in our medical content. However, this polynucleotide-based therapy is widely recognised online as the "black box" salmon DNA injection, and commonly associated with regenerative skin boosters known internationally for their collagen-stimulating, skin-healing, and DNA-repairing properties.

Unlike dermal fillers, PN injections do not add volume. Instead, they work at a cellular level to restore healthier, firmer, and more radiant skin — addressing concerns such as fine lines, acne scars, enlarged pores, and skin sensitivity.

At our clinic, PN skin therapy is carefully individualised to ensure safe, natural-looking results with minimal discomfort and downtime.ividualised to ensure safe, natural-looking results with minimal discomfort and downtime.

Benefits of Polynucleotide (PN) Skin Rejuvenation Therapy

Polynucleotide (PN) Skin Rejuvenation Therapy, often referred to online as "salmon DNA skin booster" or "Korean PN therapy," offers a wide range of benefits by harnessing the skin’s natural healing, regenerative, and collagen-repairing potential. Derived from purified salmon DNA fragments, this advanced injectable treatment is designed to restore healthy, youthful skin from within — without adding volume or altering natural facial contours.

Key benefits of PN skin rejuvenation therapy include:

Stimulates Natural Collagen and Elastin Production
Polynucleotides activate fibroblasts — the key cells responsible for producing collagen and elastin — to strengthen the skin’s internal support structure. This promotes firmer, more elastic skin over time.
Enhances Skin Texture, Hydration, and Radiance
By repairing the skin barrier and improving moisture retention, PN therapy revitalises the skin, making it softer, smoother, and visibly more luminous.
Reduces Fine Lines and Early Signs of Ageing
Regular sessions help to minimise the appearance of fine lines and superficial wrinkles, particularly in delicate areas such as the under-eyes, forehead, and cheeks.
Calms Sensitive, Inflamed, and Post-Acne Skin
Thanks to its anti-inflammatory properties, PN therapy is effective in soothing redness, sensitivity, and irritation — making it suitable for compromised or post-acne skin.
Supports Healing After Acne Scarring, Laser Treatments, and Environmental Stress
The regenerative capabilities of this salmon DNA-based therapy accelerate skin recovery, strengthen resilience against environmental damage, and enhance the skin’s ability to heal and rejuvenate.

At our Singapore clinic, every PN skin rejuvenation treatment is personalised to your skin concerns and goals. We use premium Korean formulations widely recognised online for their collagen-boosting, skin-healing, and regenerative skin booster properties, ensuring safe, effective, and natural-looking results with minimal downtime.ime.

How Polynucleotide (PN) Treatment Works for Skin Repair and Collagen Stimulation

Polynucleotide (PN) Skin Rejuvenation Therapy harnesses the skin’s natural regenerative and DNA repair processes to promote long-term repair, hydration, and collagen renewal. Using biologically active DNA fragments derived from salmon, PN therapy stimulates fibroblasts — the specialised cells responsible for producing collagen and elastin — to rebuild and strengthen the skin’s structural foundation.

Once injected, the polynucleotides initiate a cascade of regenerative responses within the dermis. These include:

Activation of Collagen and Elastin Synthesis: Supporting firmer, more elastic skin over time.
Enhancement of Skin Hydration and Barrier Function: Strengthening the skin’s natural moisture retention ability and resilience against environmental stress.
Improvement of Cell Turnover and Microcirculation: Promoting healthier, more vibrant skin texture and tone.
Reduction of Inflammation: Calming sensitive, irritated, or post-acne skin through anti-inflammatory effects.

While often referred to online as a "salmon DNA skin booster" or "black box injection," this therapy is medically classified as polynucleotide (PN) treatment. It offers a natural, regenerative approach to skin rejuvenation without adding volume or altering facial contours — unlike dermal fillers.

Every PN rejuvenation session at our medical aesthetic clinic in Singapore is personalised to suit your skin condition and goals. Treatments are spaced strategically over several sessions to stimulate natural collagen renewal and achieve gradual, long-lasting improvements in skin health and appearance.

Who Is Polynucleotide (PN) Skin Rejuvenation Therapy Suitable For?

Polynucleotide (PN) Skin Rejuvenation Therapy is ideal for individuals seeking to improve skin quality from within, using a natural, regenerative approach rather than volumising treatments like dermal fillers. At our medical aesthetic clinic in Singapore, PN therapy is commonly recommended for:

Individuals with Sensitive or Reactive Skin
PN’s calming, anti-inflammatory properties make it well tolerated by patients prone to redness, sensitivity, or weakened skin barriers.
Patients Recovering from Acne Breakouts or Inflammation
By supporting skin healing at a cellular level, polynucleotide therapy helps reduce lingering redness, promote tissue regeneration, and restore a healthier skin texture after acne.
Those Experiencing Early Signs of Ageing
If you are beginning to notice fine lines, skin roughness, or early loss of elasticity, PN therapy stimulates natural collagen production to help delay deeper ageing changes.
Individuals Undergoing Post-Laser or Post-Treatment Recovery
PN injections are often used following energy-based treatments (such as lasers or microneedling) to accelerate healing, reduce downtime, and strengthen the skin’s resilience.
People with Dull, Dehydrated, or Environmentally Stressed Skin
Salmon DNA-based PN therapy restores hydration, smoothness, and radiance to skin affected by UV exposure, air conditioning, or urban pollution.

This regenerative skin booster is particularly popular among patients seeking a subtle, natural enhancement of their skin health — without changing their facial contours or expression. Every PN skin rejuvenation treatment at our Singapore clinic is carefully tailored to your skin needs, ensuring safe, effective, and gradual improvement over time.

What to Expect During Polynucleotide (PN) Skin Rejuvenation Therapy

At our Singapore clinic, Polynucleotide (PN) Skin Rejuvenation Therapy is performed with precision and care, ensuring comfort, safety, and minimal downtime. Each treatment session is fully customised based on your skin concerns, condition, and treatment goals.

Before the procedure, your skin will be thoroughly cleansed. A topical numbing cream is typically applied to enhance comfort, especially if a larger area is being treated or if you have sensitive skin.

The salmon DNA-based polynucleotide solution is then delivered into the skin using one of two techniques, depending on your specific needs:

Manual Micro-Injection Technique

This traditional method uses a fine needle to administer small amounts of the PN solution directly into targeted areas of the skin. Manual micro-injections are ideal for precision work on delicate zones or areas with textural irregularities.

Benefits of manual micro-injections:

Enables highly targeted delivery for acne scars, fine lines, and localised concerns
Allows precise adjustment of injection depth and placement
Ideal for delicate or difficult-to-reach areas, such as the under-eye region

Dermashine Injector Device

The Dermashine Injector is a multi-needle delivery system designed to evenly distribute the polynucleotide solution across broader areas of the face or neck. It utilises a gentle vacuum suction to lift the skin before each micro-injection, ensuring consistent depth and uniform product placement.

Benefits of the Dermashine Injector:

Provides even and controlled distribution of PN across wide treatment zones
Enhances patient comfort with rapid, shallow needle entry
Reduces downtime — minor injection bumps typically subside within 1 to 2 days

Following your regenerative skin booster treatment, you may experience mild redness, swelling, or small injection marks, all of which usually resolve within a few hours to a day. Post-treatment skincare instructions will be provided to optimise healing and support your skin’s rejuvenation process.

Combining Polynucleotide (PN) Injections and Hyaluronic Acid Skinboosters in Singapore

Polynucleotide (PN) injections and hyaluronic acid (HA) skinboosters work through complementary mechanisms, and when used together, they create a powerful synergy for comprehensive skin rejuvenation.

Polynucleotide (PN) Therapy focuses on cellular regeneration and structural repair. By activating fibroblasts and stimulating collagen production, PN strengthens the skin’s internal support system, improves elasticity, and promotes long-term healing — particularly beneficial for sensitive, acne-prone, or environmentally damaged skin.

Hyaluronic Acid (HA) Skinboosters, in contrast, target hydration. Hyaluronic acid is a naturally occurring molecule that attracts and retains moisture within the skin. When delivered through microinjections, HA replenishes hydration levels, smooths fine lines, and imparts a dewy, radiant glow to the skin surface.

For individuals in Singapore seeking holistic skin rejuvenation, combining PN therapy and HA skinboosters allows for dual-action improvement:

PN rebuilds and regenerates the skin at a cellular level
HA enhances immediate hydration, suppleness, and luminosity

This combination is particularly effective for patients with dull, dehydrated, ageing, or post-acne skin, as well as for those undergoing recovery after laser or energy-based treatments.

Our medical team frequently personalises skin rejuvenation plans by layering or alternating PN and HA injections, depending on each patient's unique skin condition, treatment goals, and healing timeline. By addressing both deep structural repair and surface hydration, this synergistic approach delivers smoother, firmer, and more radiant skin — naturally and effectively.

Overview of Polynucleotide (PN) and Other Collagen-Stimulating Treatments in Singapore

Polynucleotide (PN) Injections

Commonly referred to online as "salmon DNA" skin boosters, Polynucleotide (PN) Injections stimulate fibroblasts to promote collagen production and support natural skin repair at a cellular level. Widely regarded for their regenerative effects, PN injections are ideal for improving dullness, fine lines, acne scars, and sensitive skin — particularly in Singapore’s humid urban climate.

High-Intensity Focused Ultrasound (HIFU)

High-Intensity Focused Ultrasound (HIFU) is a non-invasive ultrasound technology that lifts and firms the skin by delivering focused energy to the deep dermal and SMAS layers. Popular for facial contouring and jawline definition, HIFU treatments offer natural tightening results without downtime or invasive procedures.

Radiofrequency Microneedling (e.g., Sylfirm X)

Sylfirm X Radiofrequency Microneedling combines precision microneedling with radiofrequency energy to remodel collagen, reduce redness, refine enlarged pores, and improve skin elasticity. It is an excellent choice for patients managing rosacea, early sagging, or post-inflammatory skin texture changes common in Singapore’s climate.

PDLLA-Based Injectable Collagen Stimulators

Our PDLLA-based collagen stimulators are regenerative injectables using poly-D,L-lactic acid microparticles — a technology internationally recognised for progressive collagen rebuilding over time. Commonly associated with long-term skin firming and natural volumisation, this injectable is especially suited for younger patients seeking early preventative care or subtle mid-face enhancement.

Biostimulatory Injectables with Synthetic Microspheres

Biostimulatory injectables using synthetic microspheres utilise smooth, biocompatible microsphere technology to stimulate collagen production while providing immediate structural support. Known for producing gradual yet lasting results, this category of regenerative fillers is ideal for patients desiring subtle, natural facial contour enhancement with minimal maintenance.

Next-Generation Poly-L-Lactic Acid (PLLA) Injectables

Our next-generation PLLA-based injectables represent an evolution in collagen biostimulation, offering a gradual improvement in skin thickness, elasticity, and overall quality. Particularly effective for early collagen loss or post-acne skin texture refinement, PLLA treatments are suited for patients who prefer discreet, progressive enhancement.

Stabilised Hyaluronic Acid (HA) Bio-Remodelling Injectables

Stabilised HA bio-remodelling injectables deliver intense hydration while promoting elastin and collagen regeneration — without adding volume like traditional fillers. Ideal for achieving the coveted "healthy glow," these injectables are especially popular in Singapore for improving fine lines, skin firmness, and overall skin vitality without altering natural facial contours.

Each of these collagen-stimulating treatments provides distinct regenerative benefits and can be customised to address your specific skin needs. During your consultation at our Singapore clinic, our doctors will recommend a tailored treatment plan to help you achieve smoother, firmer, and more radiant skin — naturally and safely.

Treatment Frequency and Maintenance for Polynucleotide (PN) Injections in Singapore

Polynucleotide (PN) Skin Rejuvenation Therapy is most effective when performed as a series of treatments, with each session gradually strengthening the skin’s regenerative capacity and collagen production. To achieve optimal skin quality improvements, we typically recommend the following treatment protocol:

Initial Treatment Plan

Most patients begin with an initial course of 3 to 4 PN injection sessions, spaced approximately 3 to 4 weeks apart. This schedule allows the polynucleotides — derived from salmon DNA — to activate fibroblasts, stimulate collagen and elastin synthesis, and promote long-term skin healing. Improvements in skin hydration, elasticity, and overall texture often become noticeable after the second session and continue to enhance with each subsequent treatment.

Maintenance Treatments

To preserve the regenerative effects of PN therapy, maintenance sessions are generally recommended every 6 to 12 months. Regular maintenance helps sustain collagen production, prolong the benefits of the initial treatment series, and ensure that the skin continues to repair, renew, and resist environmental stressors over time.

Our clinic in Singapore tailors each regenerative skin booster program to the individual, considering factors such as baseline skin health, age, lifestyle, and long-term aesthetic goals. Whether you are seeking to address acne scarring, early signs of ageing, post-laser recovery, or overall skin resilience, a customised PN therapy maintenance plan ensures that your skin remains firm, hydrated, and naturally radiant over the years.

Safety and Side Effects of Polynucleotide (PN) Injections in Singapore

Polynucleotide (PN) Skin Rejuvenation Therapy is widely regarded as a safe and well-tolerated treatment when performed by trained medical professionals. At our Singapore clinic, patient safety, comfort, and optimal outcomes are prioritised at every stage of your PN therapy journey.

The polynucleotides used in these treatments are derived from salmon DNA and undergo advanced purification processes to ensure high biocompatibility with human skin. These formulations have been clinically validated for medical aesthetic use, demonstrating a very low risk of allergic reactions or adverse effects.

For more insights into the clinical science behind polynucleotide skin therapies, you may refer to this clinical review on PN therapy safety and efficacy.

Why PN Therapy Is Considered Safe

Highly Biocompatible: The polynucleotide solution is extensively purified to reduce allergenic components and maximise compatibility with human tissue.
Low Risk of Allergic Reactions: Most patients tolerate PN injections exceptionally well, with minimal incidence of sensitivity or rejection.
Clinically Supported: Multiple peer-reviewed studies support the safety and efficacy of polynucleotide treatments in stimulating collagen production, enhancing skin healing, and improving overall dermal health.

Possible Side Effects

While PN therapy is associated with minimal downtime, mild and temporary side effects may occur, including:

Redness and swelling at the injection sites, typically resolving within a few hours to two days
Small bumps immediately post-injection, usually fading within 1 to 3 days
Bruising, although uncommon, which generally clears within 3 to 5 days

These side effects are self-limiting and part of the skin’s natural healing response. To minimise downtime and maximise comfort, we utilise fine-gauge needles, optimised injection techniques, and provide tailored post-care protocols.

Post-Treatment Care Guidelines

To ensure a smooth recovery and enhance the regenerative effects of your skin booster treatment, we recommend:

Applying the post-procedure recovery cream provided by your doctor
Avoiding harsh skincare products (such as acids or retinoids) for 1 to 2 days after treatment
Limiting sun exposure and consistently applying broad-spectrum sunscreen
Avoiding strenuous physical activity for 24 hours to reduce the risk of swelling or irritation

Should you experience any unexpected symptoms following your Polynucleotide (PN) injection, our clinic team is readily available to provide support and guidance throughout your recovery process.through the recovery process.

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How to Choose the Best Clinic for Polynucleotide (PN) Skin Rejuvenation Therapy in Singapore

When considering Polynucleotide (PN) Skin Rejuvenation Therapy, it is important to select a trusted and experienced medical aesthetic clinic to ensure your safety, treatment quality, and overall satisfaction.

Here are important factors to consider when choosing the best clinic for PN skin rejuvenation in Singapore:

1. Doctor-Led Treatments

Always ensure that PN injections are performed by qualified medical doctors. An experienced doctor understands facial anatomy, regenerative mechanisms, and safe injection techniques — all essential for achieving optimal, natural-looking results.

2. Expertise in Regenerative Skin Therapies

Select a clinic with extensive experience in regenerative skin treatments, particularly in polynucleotide-based therapies. Clinics familiar with collagen stimulation and skin repair procedures can better personalise your treatment plan to suit your specific concerns.

3. Personalised Consultation and Individual Assessment

The best outcomes are achieved when treatment plans are tailored to the individual. Look for clinics that offer thorough consultations to assess your skin condition, medical history, and lifestyle factors before recommending a PN therapy approach.

4. Clear Communication and Comprehensive Aftercare

A reputable clinic will clearly explain the expected outcomes, downtime, possible side effects, and aftercare instructions. Comprehensive post-treatment support is important to ensure a smooth recovery and maximise the regenerative benefits of PN therapy.

5. Positive Patient Reviews and Proven Results

Clinics with strong patient feedback, visible before-and-after results, and a consistent track record in regenerative skin treatments provide greater confidence in the quality of care and results you can expect.

Ready to Begin Your Skin Rejuvenation Journey?

If you are considering Polynucleotide (PN) Skin Rejuvenation Therapy to improve your skin’s hydration, elasticity, and overall radiance, our clinic is here to help. We provide doctor-led, personalised treatment plans designed to support your skin’s natural regeneration safely and effectively.

Schedule a consultation with our experienced medical team today to find out how PN therapy can be tailored to your unique skin goals.
Let us guide you towards achieving firmer, healthier, and more radiant skin — naturally.

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Frequently Asked Questions (FAQ) About Polynucleotide Skin Rejuvenation Treatments

Is Polynucleotide (PN) Skin Rejuvenation Therapy safe?

Yes, Polynucleotide (PN) injections, commonly recognised under brand names such as Rejuran Healer, are widely regarded as safe when performed by trained medical professionals. The polynucleotides used are extracted from purified salmon DNA and undergo advanced purification to ensure high biocompatibility with human skin.

Clinical studies consistently demonstrate the safety and effectiveness of Rejuran in promoting collagen production, skin healing, and regenerative anti-ageing outcomes. For more insights into the clinical science behind Rejuran, you may refer to this clinical review on Rejuran therapy safety and efficacy.

How Long Do the Results Last?

Results from Rejuran Healer rejuvenation treatments typically last between 6 to 12 months. The longevity of the results can vary based on factors such as skin condition, age, and lifestyle. Maintenance treatments every 6 to 12 months are often recommended to sustain collagen production and maintain skin improvements.

What Is The Downtime After Polynucleotide (PN) Therapy?

Downtime following Rejuran Healer is minimal. You may experience mild redness, slight swelling, or small bumps at the injection sites immediately after the session. These typically subside within a few hours to two days. Compared to more intensive energy-based treatments, Rejuran Healer injections offer a relatively quick recovery, allowing most patients to resume daily activities within 24 hours.

Is the PN treatment painful?

Most patients experience minimal discomfort during a Rejuran Healer injection session. A topical numbing cream is applied before the procedure to ensure comfort. Patients typically describe the sensation as light pinpricks or pressure, similar to the experience during Botox injections or Skinbooster treatments. Mild tenderness, if any, usually subsides shortly after the session.

Additionally, delivery methods such as the Dermashine injector gun ensure even distribution with controlled depth, minimizing discomfort.

How Soon Can I See Results?

Initial improvements in skin hydration and glow can often be seen within 2 to 4 weeks after the first Rejuran Healer session. However, the full regenerative effects, including collagen stimulation and enhanced skin elasticity, usually develop progressively over a course of treatments. This is similar to other regenerative skin therapies such as Juvelook and bio-remodelling injectables like Profhilo, where improvements continue to build over several months.

Can Polynucleotide Treatments Be Combined With Other Skin Procedures?

Yes, Rejuran Healer treatments can complement other aesthetic procedures to enhance overall skin rejuvenation. Common combinations include:
- Laser treatments for pigmentation and acne.
- Hyaluronic acid skinboosters for enhanced hydration.
- Ellanse PCL collagen stimulating fillers or HA fillers for volume restoration
Consult your doctor to create a tailored treatment plan that addresses your skin goals comprehensively.

Who Is an Ideal Candidate for Polynucleotide Skin Rejuvenation?

Rejuran Healer Skin Rejuvenation Therapy, commonly associated with salmon DNA-based injectables, is suitable for individuals seeking natural skin revitalisation without volumisation.

It is ideal for those who are experiencing:
- Fine lines and early wrinkles
- Mild to moderate skin laxity or reduced firmness
- Uneven skin texture, enlarged pores, or roughness
- Dehydrated, dull, or environmentally stressed skin
- Post-acne scarring or weakened skin barrier function

Rejuran Healer therapy is well-suited for individuals who prefer regenerative, gradual improvements in skin quality rather than immediate volumising effects from traditional dermal fillers. It is also an excellent option for patients looking to complement other aesthetic procedures such as skinboosters, botulinum toxin (Botox), or bio-remodelling injectables like Profhilo.

A detailed consultation with our experienced doctors in Singapore will help assess your skin condition and determine if Rejuran Healer therapy is the most appropriate treatment for your goals.

Is There Any Pre-Treatment Preparation Required?

Patients are advised to take the following steps before Rejuran Healer treatment to reduce the risk of bruising or irritation:
- Avoid alcohol and blood-thinning medications (e.g., aspirin) for 48 hours prior to the procedure unless instructed otherwise by your doctor.
- Refrain from applying active skincare products, such as retinol or AHAs, to the treatment area for a few days before the procedure.

What Should I Avoid After the Treatment?

To optimize results and minimize side effects, follow these Rejuran Healer post-treatment guidelines:
- Avoid makeup application on the treated area for at least 24 hours.
- Refrain from strenuous physical activities, saunas, or hot baths for 24 hours.
- Protect the treated area from excessive sun exposure and follow all aftercare instructions provided by your doctor.

How Many Sessions of PN Injections Are Needed?

For optimal Rejuran Healer results, we typically recommend an initial course of 3 to 4 sessions, spaced about 3 to 4 weeks apart. This schedule allows cumulative collagen stimulation and skin healing. Maintenance sessions every 6 to 12 months help sustain the results over time. This maintenance protocol is also common in other regenerative injectable treatments such as Juvelook and Skinboosters.

Are There Different Types of Polynucleotide (PN) Skin Rejuvenation Treatments?

Yes, there are different formulations of Rejuran Polynucleotide Skin Rejuvenation Therapy, each designed to target specific skin concerns. While the core regenerative mechanism remains the same — stimulating collagen production and promoting skin repair — different variations are optimised for particular treatment goals.

Some commonly known options include:
Under-Eye Rejuvenation (Rejuran Eye):
This formulation is designed for the delicate under-eye area to improve fine lines, dark circles, and thinning skin, where the skin is more fragile and prone to early ageing.

Scar Repair (Rejuran Scar):
Specifically developed for scarred or damaged skin, this version focuses on stimulating tissue regeneration and improving skin texture, particularly for post-acne scarring.

Hydration and Skin Quality Enhancement (Rejuran HB / Hydroboost):
This formulation is tailored to deliver intense hydration, improving overall skin radiance, elasticity, and resilience — ideal for dehydrated, tired, or environmentally stressed skin.

During your consultation, our doctors will carefully assess your skin condition and recommend the most suitable Rejuran therapy formulation based on your individual concerns and treatment goals.

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