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Disclaimer: In line with HSA regulations in Singapore, we are unable to mention brand names directly on this page.
However, the popular once-weekly semaglutide injection — widely used overseas for weight loss and developed by a leading Danish pharmaceutical company — is now available at our clinic.
Interested in the “Oz” once- weekly weight loss injection?
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Introduction to Weekly Semaglutide (GLP-1) Injections for Weight and Diabetes Management
In recent years, GLP-1 receptor agonist injections have emerged as a popular and medically effective option for patients struggling with weight issues, obesity-related conditions, or type 2 diabetes. In Singapore, these weekly semaglutide treatments are prescribed as part of a holistic approach to managing metabolic health under professional supervision.
Whether you're facing challenges with weight management, insulin resistance, or looking for medical support beyond lifestyle changes alone, GLP-1 therapy may be a suitable option. This page outlines what these treatments are, how they work, and what to expect if you're considering them as part of your care plan.
What Are Semaglutide (GLP-1) Weight Loss Injections
GLP-1 weight loss injections are doctor-prescribed medications used to support weight loss and improve blood sugar control, especially in individuals with obesity, insulin resistance, or type 2 diabetes. These treatments are typically recommended when lifestyle changes such as diet and exercise alone have not produced sufficient results.
They contain active ingredients such as semaglutide (administered once weekly) and liraglutide (administered once daily), both of which belong to a class of medications known as GLP-1 receptor agonists.
These injections are designed to work alongside a healthy lifestyle and are prescribed based on each patient’s medical profile. When used under professional supervision, GLP-1 therapies can lead to clinically meaningful and sustainable weight loss, while also helping to manage metabolic health and reduce the risk of obesity-related conditions.
How Do Semaglutide (GLP-1) Weight Loss Injections Work?
GLP-1 receptor agonist injections target the biological processes that contribute to weight gain, insulin resistance, and metabolic dysfunction. These medications work through several key mechanisms that support effective and sustained weight loss, while also improving glucose regulation in individuals with or without type 2 diabetes.
Appetite Regulation
GLP-1 medications mimic the action of the body’s natural GLP-1 hormone, which helps signal the brain to reduce appetite and enhance satiety. This leads to decreased food cravings, smaller portion sizes, and better control over calorie intake.
Slowed Gastric Emptying
These treatments delay the rate at which the stomach empties food into the intestines. As a result, patients feel full for longer after meals, making it easier to reduce snacking and maintain a caloric deficit.
Improved Glucose Control
For individuals with type 2 diabetes or insulin resistance, GLP-1 injections enhance insulin sensitivity and reduce post-meal blood glucose levels. This dual action not only aids in weight management, but also supports overall metabolic health.
When combined with a healthy diet and regular physical activity, GLP-1 therapy can lead to long-term improvements in weight, glucose levels, and even cardiovascular risk factors such as blood pressure and cholesterol.
Overview of Semaglutide (GLP-1) Weight Loss Injections in Singapore
In Singapore, several GLP-1 receptor agonist medications are available to support weight loss and blood sugar regulation, depending on your individual health profile and treatment goals. These include both injectable and oral formulations prescribed under medical supervision.
Semaglutide (Injectable, Once Weekly)
A once-weekly injection originally developed for managing type 2 diabetes, semaglutide has also shown strong potential in promoting weight loss, even in individuals without diabetes. While not currently approved solely for weight management in Singapore, clinical studies have reported average weight reductions of 5–15%, along with improvements in cardiovascular health, blood pressure, and metabolic function.
Liraglutide is a once-daily GLP-1 injection used for weight management in individuals with overweight or obesity, including some adolescents. It works by regulating appetite, reducing calorie intake, and helping patients adhere to long-term lifestyle changes. Clinical trials have shown average weight loss of 5–10% when used alongside a healthy diet and regular exercise.
An oral form of semaglutide is also available in Singapore, primarily for the treatment of type 2 diabetes. It offers similar metabolic benefits and can assist with weight reduction, making it a suitable alternative for patients who prefer tablets over injections.
Your doctor will determine the most appropriate GLP-1 therapy based on your medical history, BMI, blood sugar levels, and overall health goals. These treatments are most effective when combined with lifestyle modifications and monitored by an experienced doctor.
What Results Can You Expect from Weekly Semaglutide (GLP-1) Injections?
Weekly semaglutide (GLP-1) injections have shown promising results in both clinical trials and real-world practice for weight loss and metabolic improvement. Results vary between individuals, but most patients experience measurable changes in appetite, energy levels, and weight within the first few weeks of treatment.
Timeline of Expected Outcomes:
- Weeks 1–2:
Many patients notice reduced appetite and improved satiety, leading to smaller portion sizes and fewer cravings.
- Weeks 4–8:
Initial weight loss becomes more noticeable. Some patients lose around 2–5% of their body weight during this period, depending on dosage and adherence to diet and exercise.
- 3–6 Months:
Continued weight loss is typically observed, often reaching 5–10% of starting body weight, along with improvements in blood sugar, cholesterol, and blood pressure.
- 6 Months and Beyond:
In longer-term studies, patients have achieved up to 15% weight loss over 12–18 months, particularly when the treatment is combined with lifestyle modifications and regular follow-up.
- Source: Wilding et al., New England Journal of Medicine, 2021; STEP 1 trial
Results may vary based on individual factors such as starting weight, metabolic health, activity level, and consistency with treatment. Regular follow-up with your doctor ensures safe and sustainable progress.
Benefits of Weekly Semaglutide (GLP-1) Weight Loss Injections
When prescribed appropriately and used under medical supervision, GLP-1 weight loss injections offer a range of health benefits for individuals struggling with obesity, type 2 diabetes, or metabolic syndrome. These benefits go beyond weight reduction and contribute to overall long-term health improvement.
Sustainable Weight Loss
GLP-1 injections help patients lose weight steadily by reducing appetite, improving satiety, and supporting adherence to a lower-calorie diet. When combined with lifestyle changes, they have been shown to produce clinically meaningful, long-term weight reduction.
Improved Blood Sugar Control
These medications lower post-meal glucose levels, improve insulin sensitivity, and reduce HbA1c—making them particularly beneficial for individuals with type 2 diabetes or prediabetes.
Cardiovascular Health Support
Clinical studies have shown that GLP-1 therapies may reduce blood pressure, improve lipid profiles, and lower the risk of major cardiovascular events in certain patients—offering benefits beyond weight and glucose control.
Lifestyle Support and Appetite Regulation
By reducing cravings and making it easier to stick to healthier eating habits, GLP-1 injections can improve compliance with nutritional and exercise plans, which are critical to long-term weight management success.
Who Is a Suitable Candidate for Semaglutide (GLP-1) Therapy?
GLP-1 therapy may be recommended for individuals with obesity, type 2 diabetes, or weight-related metabolic conditions who have not responded adequately to lifestyle modifications alone. Below are common criteria used to assess suitability for treatment:
1. Body Mass Index (BMI)
A BMI of 30 or higher (classified as obese), or 27 and above with associated medical conditions such as hypertension, insulin resistance, or dyslipidemia (elevated cholesterol), may indicate eligibility for GLP-1 therapy.
2. Type 2 Diabetes or Prediabetes
Individuals diagnosed with type 2 diabetes, prediabetes, or metabolic syndrome may benefit from the glucose-lowering and appetite-regulating effects of GLP-1 medications. These treatments can improve glycaemic control and support weight loss simultaneously.
3. Limited Response to Lifestyle Changes
GLP-1 therapy may be appropriate for patients who have struggled to achieve significant weight loss despite consistent efforts with diet, exercise, and behavioral strategies.
4. Willingness to Engage in Ongoing Medical Supervision
Since GLP-1 medications require regular follow-up, dose titration, and monitoring for side effects, ideal candidates are those committed to participating in a doctor-supervised weight loss program.
A comprehensive medical consultation is essential to determine whether GLP-1 therapy is appropriate for your individual needs. Our doctors will thoroughly evaluate your medical history, current health status, and weight management goals to create a personalised, evidence-based treatment plan tailored to your unique profile.
How Are Weekly Semaglutide (GLP-1) Weight Loss Injections Administered?
GLP-1 weight loss injections are usually self-administered subcutaneous injections delivered just under the skin using a pre-filled injection pen. Most patients find the process straightforward and manageable after proper instruction from their doctor.
Step-by-Step Guide to Self-Administration:
- Choose an Injection Site
Select a clean area on the abdomen, thigh, or upper arm that is free of bruises, scars, or irritation.
- Clean the Skin
Use an alcohol swab to disinfect the site and let it dry completely before injecting.
- Prepare the Injection Pen
Attach a new needle and prime the pen by releasing a small drop of medication to ensure proper flow.
- Administer the Injection
Gently pinch the skin, insert the needle at a 90-degree angle, and press the plunger to deliver the full dose. Hold for a few seconds before removing.
- Post-Injection Care
Remove the needle and press lightly on the injection site with a sterile cotton ball or alcohol swab. Do not rub the area.
- Rotate Injection Sites
To minimize skin irritation or tissue buildup, rotate your injection site with each dose.
Always follow your doctor’s instructions and the usage guide that comes with your prescribed GLP-1 medication. Correct technique helps ensure optimal absorption and reduces the risk of injection-related side effects.
Side Effects and Risks of Semaglutide (GLP-1) Weight Loss Injections
GLP-1 receptor agonist medications are generally safe and well-tolerated when prescribed and monitored by a doctor. However, like all treatments, they may cause side effects. These can range from mild digestive discomfort to rare but serious medical conditions. Understanding these risks helps you make an informed decision with your doctor.
Common Side Effects
Most side effects are mild and tend to improve as your body adjusts to the medication:
- Nausea
- Constipation or diarrhea
- Bloating or indigestion
- Mild discomfort, redness, or itching at the injection site
Less Common Side Effects
These may affect a smaller group of patients:
- Dizziness or lightheadedness
- Fatigue
- Mild headache
- Changes in appetite
Rare but Serious Risks
Although rare, some patients may experience:
- Pancreatitis (inflammation of the pancreas)
- Gallbladder issues, such as gallstones
- Thyroid complications, especially in those with a personal or family history of thyroid conditions
Contraindications
GLP-1 receptor agonists are contraindicated in individuals with:
- Personal or family history of Medullary Thyroid Carcinoma (MTC): These medications may increase the risk of thyroid C-cell tumors.
- Multiple Endocrine Neoplasia syndrome type 2 (MEN2): Due to potential risks, GLP-1 receptor agonists should not be used in patients diagnosed with MEN2.
It’s important to share your complete medical history with your doctor before starting treatment—especially if you have existing gastrointestinal, gallbladder, or thyroid concerns.
Your doctor can help you weigh the potential benefits against the risks based on your individual health profile, and will monitor for any adverse effects throughout the treatment course.
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Finding the Best Clinic for Weekly Semaglutide (GLP-1) Weight Loss Injections
Choosing a trusted medical clinic is essential for safe, effective, and personalized GLP-1 weight loss treatment. A well-managed program can significantly improve your health outcomes and ensure long-term success. Here are key factors to consider when selecting a clinic:
What to Look For:
- Comprehensive Medical Consultation
The clinic should begin with a detailed assessment of your weight history, metabolic profile, and underlying health conditions to determine if GLP-1 therapy is appropriate for you.
- Access to Multiple Treatment Options
Clinics that offer a range of evidence-based weight loss solutions—including both injectable and oral GLP-1 medications—can better tailor your plan to your needs and preferences.
- Experienced, Doctor-Led Team
Ensure the clinic is staffed by qualified doctors with experience in obesity care, metabolic health, and GLP-1 prescribing protocols.
- Ongoing Support and Monitoring
Look for clinics that provide regular follow-ups, side effect monitoring, and long-term lifestyle guidance to help you stay on track with your goals.
By working with a reputable clinic, you benefit from a treatment plan that’s not only medically sound but also personalized to your body and lifestyle. Medical oversight plays a key role in ensuring the safety and effectiveness of GLP-1 weight loss therapy.
Frequently Asked Questions (FAQs)
1. Is semaglutide approved for weight loss in Singapore?
In Singapore, semaglutide — including branded versions like Ozempic — is currently approved for the treatment of type 2 diabetes. While not specifically approved for weight loss, doctors may prescribe it off-label for patients with obesity or weight-related health concerns, based on clinical evidence and international guidelines.
2. Can I take GLP-1 injections if I don’t have diabetes?
Yes, GLP-1 medications such as semaglutide (including Ozempic) may be prescribed to individuals without diabetes, especially those with a BMI of 30 or above, or 27 with conditions like high blood pressure or high cholesterol. Your doctor will determine your suitability during a comprehensive medical assessment.
3. How quickly can I expect to see results from semaglutide or GLP-1 therapy?
Patients on semaglutide-based treatments such as Ozempic often notice reduced appetite within the first few weeks. Weight loss progress typically becomes visible after 4 to 8 weeks, depending on dosage, individual response, and accompanying lifestyle habits.
4. Do I need to follow a special diet while on GLP-1 injections?
While there’s no required diet for those on GLP-1 therapy, including Ozempic, optimal results are usually achieved by following a balanced, calorie-conscious eating plan and engaging in regular exercise. These lifestyle adjustments enhance the appetite-regulating effects of the medication.
5. Are there any long-term risks of taking GLP-1 medications like semaglutide?
GLP-1 medications, including Ozempic, are generally well-tolerated. However, in rare cases, they may cause side effects such as pancreatitis, gallbladder issues, or thyroid-related conditions. Your doctor will monitor your response and adjust your treatment as needed to ensure safety.
6. Can I stop taking the injections after I reach my goal weight?
Discontinuing semaglutide (including Ozempic) may lead to weight regain, particularly if lifestyle habits are not well established. Your doctor can guide you on how to taper or transition off treatment safely while maintaining results.
Summary
GLP-1 weight loss injections are a medically proven approach to managing obesity, type 2 diabetes, and related metabolic conditions. By regulating appetite, improving insulin response, and supporting long-term lifestyle changes, these treatments can lead to meaningful and sustainable results when used under proper medical supervision.
While generally safe, GLP-1 therapies may carry side effects and are not suitable for everyone. A thorough medical consultation is essential to determine whether this treatment is appropriate for your health profile.
Choosing a reputable clinic that offers personalized care, access to multiple GLP-1 options, and ongoing support is key to achieving safe and effective weight loss. With professional guidance, you can take a structured and medically sound approach toward your long-term health goals.
