Disclaimer: In accordance with HSA regulations in Singapore, we are unable to mention specific brand names on this page.
However, the popular once-weekly semaglutide injection is now available at our clinic. Enquire Now! to WhatsApp us and speak with our team directly to learn more.
Weight loss is a complex journey influenced by hormones, metabolism, and lifestyle. For individuals struggling with obesity or weight-related health conditions, weekly GLP-1 receptor agonist injections containing semaglutide have emerged as a powerful treatment option.
These injections mimic the body’s natural satiety hormones, helping to reduce appetite and improve metabolic control — all with the convenience of once-weekly dosing.
In this guide, we explore how semaglutide works, what to expect during treatment, and how it fits into a medically supervised weight loss program in Singapore. This page is intended to educate and support patients considering this approach, based on clinical evidence and medical guidance.
Semaglutide is a type of medication known as a GLP-1 receptor agonist. It was originally developed to treat type 2 diabetes, but has since gained widespread popularity overseas for its effectiveness in supporting weight loss — particularly in individuals with obesity or weight-related metabolic conditions.
Semaglutide was developed by a leading pharmaceutical company based in Denmark and is now internationally prescribed under various brand names. Due to local regulatory guidelines, specific brand names are not mentioned here.
In the body, semaglutide works by:
Unlike some other weight loss medications that require daily dosing, semaglutide is typically administered once weekly, making it convenient and easy to incorporate into a long-term medical weight loss plan.
Weekly semaglutide injections have been widely studied and used internationally as part of a medically supervised weight loss program. When prescribed appropriately and combined with lifestyle modifications, semaglutide offers several meaningful benefits:
Potential Improvement in Cardiometabolic Markers
Weight loss with semaglutide may also lead to improvements in blood pressure, cholesterol levels, and markers of inflammation.
Clinically Proven Weight Loss
Long-term studies have shown average weight reductions of up to 15% of body weight with sustained use of semaglutide.
Reduced Appetite and Cravings
Helps regulate hunger signals, making it easier to eat smaller portions and reduce snacking or emotional eating.
Improved Blood Sugar Control
Originally developed for diabetes, semaglutide also helps reduce post-meal blood sugar spikes, even in non-diabetic patients with insulin resistance.
Supports Sustainable Lifestyle Changes
By making it easier to control food intake, patients often find it more manageable to implement healthier eating habits and regular exercise routines.
Convenient Once-Weekly Dosing
Compared to daily weight loss medications, weekly injections are easier to remember and fit into a busy schedule.
Weekly semaglutide injections are typically prescribed as part of a medically supervised weight loss plan for individuals who meet specific health and eligibility criteria. While it is not a quick fix, semaglutide may be beneficial for those who have found it difficult to achieve and sustain weight loss through lifestyle changes alone.
You may be considered suitable for semaglutide treatment if you:
Every patient is assessed individually. At our clinic, a detailed medical consultation is performed before starting any treatment to ensure it is safe, appropriate, and tailored to your specific needs.
While weekly semaglutide injections have become increasingly popular for their effectiveness, they are not the only GLP-1-based treatment option available. Several other medications have also been approved for weight management, each with differences in dosing schedule, delivery method, and clinical effectiveness.
Some of the commonly prescribed alternatives include:
Daily Liraglutide Injections
A once-daily injectable GLP-1 receptor agonist that also supports weight loss by suppressing appetite and slowing gastric emptying. Learn more here
Weekly GLP-1 Injections (Other Brands of Semaglutide)
Other formulations of weekly semaglutide may differ slightly in dose range and clinical use, depending on brand and indication. Learn more here
Oral Semaglutide
The first oral GLP-1 receptor agonist available in pill form. While primarily indicated for diabetes, it may support weight loss in certain patients. Learn more here
Dual GLP-1/GIP Receptor Agonists (Tirzepatide)
A newer type of once-weekly injection that activates both the GLP-1 and GIP receptors. This dual mechanism is designed to regulate appetite, improve metabolic function, and support weight management. Learn more here
Semaglutide is a GLP-1 receptor agonist, a class of medication that mimics the action of a natural hormone in the body called glucagon-like peptide-1 (GLP-1). This hormone plays a crucial role in regulating blood sugar, appetite, and digestion — all of which contribute to weight balance.
Here’s how GLP-1 works in the body:
In people with obesity or insulin resistance, the natural GLP-1 response may be diminished — leading to increased hunger, higher blood sugar levels, and difficulty losing weight.
As a GLP-1 receptor agonist, semaglutide activates these same pathways, resulting in:
By targeting both the metabolic and behavioural aspects of weight gain, semaglutide supports safe and sustainable weight loss when used under medical supervision.
Weekly semaglutide injections are administered subcutaneously, meaning just beneath the skin. Common injection sites include the abdomen, thigh, or upper arm. The treatment follows a structured titration plan to gradually increase the dosage, helping to minimise side effects while supporting sustained weight loss.
Below is an overview of the typical treatment journey. Individual dosing schedules may vary depending on your response and medical history.
The timing and extent of results from weekly semaglutide injections can vary based on individual factors such as:
However, clinical studies have shown encouraging outcomes for many patients. Here’s a general semaglutide weight loss timeline based on trial data and clinical use.
In addition to weight reduction, weekly semaglutide has been shown to improve:
These improvements contribute to a lower overall risk of metabolic and cardiovascular disease.
The ideal duration of treatment with weekly semaglutide can vary depending on several factors, including your starting weight, weight loss goals, and response to the medication. There is no fixed treatment length — this decision should be made in consultation with your doctor.
In the STEP 4 clinical trial, participants who remained on semaglutide for up to 104 weeks (2 years) continued to see sustained weight loss benefits.
It’s important to understand that semaglutide is not a “quick fix” or permanent cure for obesity. Like medications used for diabetes or high blood pressure, it is often part of a longer-term medical strategy. If treatment is stopped, appetite may return to baseline, and some degree of weight regain may occur without continued lifestyle support.
Some patients may need to stay on treatment longer to maintain their progress, while others may be able to transition to lifestyle-based maintenance after reaching their weight loss goals.
Regular follow-up consultations are important to evaluate your progress and discuss when — or if — treatment can be tapered or discontinued.
As with any medication, weekly semaglutide injections may cause side effects. Most are mild and temporary, especially as your body adjusts during the early stages of treatment. Your doctor will evaluate the potential risks and benefits before starting you on this medication.
These are typically gastrointestinal in nature and tend to lessen with time:
If these persist or affect your daily life, let your doctor know — dosage adjustments or supportive medications may help.
Some individuals may experience:
These side effects are usually mild and improve as treatment continues.
Though uncommon, the following side effects may require urgent medical attention:
If you experience any of the above symptoms, seek medical advice promptly.
Weekly semaglutide has been shown in clinical trials to be well-tolerated by most patients, with a safety profile that supports long-term use under medical supervision. Regular follow-ups allow your doctor to monitor for side effects, make dose adjustments, and ensure your treatment remains both safe and effective.
Talk to Dr Edwin today!
Choosing the right clinic for weight loss treatment is an important step toward achieving safe and sustainable results. Here are a few key factors to consider:
Ensure that the clinic is led by experienced doctors who are trained in prescribing and administering weekly semaglutide weight loss injections. These treatments require medical oversight to ensure they are used safely and effectively.
Look for clinics that customise medical weight loss protocols based on your individual health profile — including weight history, metabolic conditions, and lifestyle factors. A tailored approach helps improve long-term outcomes.
The best clinics offer more than just a prescription. Ongoing follow-up, dose adjustments, nutritional guidance, and side effect management are essential components of a successful medical weight loss journey.
A reputable clinic will clearly explain your treatment options, expected outcomes, potential risks, and overall cost — without pressure selling or unnecessary upselling.
Read verified reviews and testimonials to understand the clinic’s track record and patient satisfaction. Consistent positive feedback is often a reflection of high-quality care.
Ultimately, the best weight loss clinic in Singapore combines clinical expertise with personalised support — helping you navigate every step of your treatment safely and confidently.
If you’re considering medical weight loss using weekly GLP-1 injections such as semaglutide, it’s important to begin with a proper medical evaluation. At our clinic in Singapore, we offer personalised treatment plans designed to support sustainable fat loss under close doctor supervision.
Your journey begins with a one-on-one consultation to assess your health profile, weight history, and treatment goals. From there, we’ll guide you through evidence-based options — including once-weekly injectable treatments — and provide ongoing support throughout your program.
Book a consultation with us today to find out if you’re a suitable candidate for medically guided weight management.