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Dr Edwin Lim
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The popular once-weekly semaglutide injection — widely used overseas for weight loss and developed by Novo Nordisk — is now available at our clinic.
Interested in the once- weekly weight loss injection?Enquire Now! to WhatsApp us and speak with our team directly.
Achieving long-term weight loss remains a significant challenge for many individuals in Singapore, even with dedicated efforts in diet and exercise. As a result, prescription weight loss injections have become an important part of doctor-supervised weight management, offering an additional solution for those who need medical support.
Developed by internationally recognised pharmaceutical companies such as Novo Nordisk and Eli Lily, these injectable medications have been widely adopted in clinical practice and are clinically proven to support healthy, sustainable weight loss for suitable patients.
Weight loss injections are prescription medications used to support individuals in Singapore who face challenges achieving weight loss through traditional methods such as diet and exercise alone. These treatments are generally recommended for adults with obesity, or those with weight-related health conditions like type 2 diabetes, high blood pressure, or high cholesterol.
Unlike over-the-counter supplements, weight loss injections require a prescription from a qualified healthcare professional and ongoing medical supervision. These medications are supplied in convenient pre-filled injectable pens, allowing patients to self-administer the injection subcutaneously—usually in the abdominal area—after receiving proper training from their doctor.
There are two main categories of prescription weight loss injections available in Singapore:
GLP-1 receptor agonist injections: These are available as both daily and once-weekly formulations, developed by pharmaceutical companies such as Novo Nordisk.
Dual-action GLP-1/GIP receptor agonist injections: These newer injectables, produced by companies like Eli Lilly, offer an additional mechanism targeting another metabolic hormone.
Weight loss injections are designed to be part of a comprehensive medical weight management program that also includes nutritional guidance, increased physical activity, and ongoing behavioural support. As with any medication, it is important to consult with your doctor to determine suitability, assess potential benefits and risks, and ensure safe use.
How Do Weight Loss Injections Work?
Prescription weight loss injections work by influencing the body's natural hormonal systems that control hunger, fullness, and metabolism. The most widely prescribed medications in Singapore target the glucagon-like peptide-1 (GLP-1) receptor, a key hormone involved in appetite regulation.
By mimicking the action of GLP-1, these injections slow down the rate at which the stomach empties after a meal and help regulate blood sugar levels. This process sends signals of satiety to the brain, making it easier for individuals to feel full with less food and to experience reduced hunger between meals.
Some injectable medications, produced by companies such as Eli Lilly, also stimulate the glucose-dependent insulinotropic polypeptide (GIP) pathway in addition to GLP-1. This dual-action mechanism provides even stronger appetite suppression and greater metabolic benefits, resulting in more significant and sustained weight loss for appropriate patients.
Rather than simply burning fat or speeding up metabolism, weight loss injections address the underlying hormonal factors that often make long-term weight control difficult. When used as part of a doctor-supervised program that includes dietary changes and increased physical activity, these medications can help patients overcome persistent barriers to weight loss and achieve healthier, lasting results.
The Benefits of Weight Loss Injections in Singapore
Weight loss injections, when used as part of a comprehensive weight management program that includes diet and exercise, can offer several benefits:
By supporting appetite control and lowering overall calorie intake, these medications enable patients to lose more weight compared to lifestyle changes alone. When integrated into a doctor-supervised program, they offer an effective pathway toward reaching and sustaining weight loss goals.
Improved Health Markers
Weight loss achieved through medically prescribed injections can lead to notable improvements in various health markers. Patients often experience better blood pressure regulation, reduced cholesterol levels, and improved blood sugar control. These benefits help to lower cardiovascular risk and support overall metabolic health, which is particularly important for those with pre-existing conditions or risk factors.
Reduced Risk of Weight-Related Health Conditions
Overweight and obesity are associated with a greater risk of serious health conditions such as heart disease, type 2 diabetes, and certain types of cancer. By helping individuals achieve and maintain significant weight loss, these injections can contribute to a lower risk of developing weight-related diseases. This protective effect adds to the overall health value of medical weight management.
Psychological Benefits
Beyond the physical advantages, successful weight loss can provide psychological benefits as well. Many patients report increased self-confidence, a more positive body image, and enhanced overall quality of life. These improvements can further motivate individuals to maintain healthy habits and sustain their progress over the long term.
Support for Individuals With Obesity-Related Health Conditions
For those managing obesity-related conditions such as type 2 diabetes or high blood pressure, weight loss injections can offer additional support that extends beyond lifestyle modification alone. These prescription therapies may be especially beneficial for patients who have struggled to lose weight through conventional approaches and need a more comprehensive, doctor-led treatment plan.
Long-Term Weight Management
Some prescription weight loss injections are suitable for long-term use, supporting ongoing appetite control and weight maintenance. Sustaining weight loss over time is often one of the greatest challenges in weight management, and these therapies can play a valuable role in helping patients avoid weight regain.
It is important to remember that while weight loss injections offer many benefits, they are not a stand-alone solution. The most successful results are achieved when these medications are used as part of a holistic program that includes dietary adjustments, physical activity, and behavioural change under professional supervision.
What Are The Differences Between the Main Prescription Weight Loss Injections in Singapore?
There are several prescription injectable medications widely used for weight management in Singapore. While these treatments work via similar biological pathways to help regulate appetite and support weight loss, they differ in dosage, frequency of administration, and specific approved uses.
Below is a comparison of the main types commonly prescribed in Singapore, all developed by leading pharmaceutical manufacturer Novo Nordisk:
Daily GLP-1 Receptor Agonist (Liraglutide)
This daily injectable medication is based on liraglutide, a GLP-1 receptor agonist. Patients administer the injection subcutaneously once every day. By mimicking the effects of natural appetite-regulating hormones, this treatment helps reduce calorie intake and supports gradual, sustained weight loss.
The daily GLP-1 injection is generally prescribed for adults who are overweight or obese, particularly if they have additional health issues such as high blood pressure or elevated cholesterol.
This once-weekly injectable pen contains semaglutide, a GLP-1 receptor agonist with a long-acting formulation. While it is most commonly prescribed to improve blood sugar control in adults with type 2 diabetes, clinical studies have shown that it also supports weight loss. The once-weekly dosing can be more convenient for some patients compared to daily injections.
High-Dose Once-Weekly GLP-1 Injection (Semaglutide Weight Loss Pen)
This prescription weight loss pen uses a higher dose of semaglutide than the standard version and is specifically approved for chronic weight management. Patients administer the injection once per week.
Studies have demonstrated that this higher-dose formulation can lead to significant weight loss when combined with healthy lifestyle changes, particularly for adults with overweight or obesity and at least one related health condition.
Dual-action GLP-1/GIP receptor agonist injections, developed by pharmaceutical company Eli Lilly, represent an important addition to medical weight management in Singapore. Unlike traditional GLP-1 injections, these once-weekly injectables mimic the action of both the GLP-1 and GIP (glucose-dependent insulinotropic polypeptide) hormones—two naturally occurring peptides that play key roles in appetite regulation and metabolic health.
By targeting both pathways simultaneously, dual-action injections provide enhanced appetite suppression, improved feelings of fullness after eating, and greater support for sustained weight loss. Clinical studies have shown that tirzepatide-based treatments can deliver more significant weight loss outcomes compared to single-hormone injectables, when combined with lifestyle changes and ongoing medical supervision.
These injections are administered once weekly and are approved in several major countries for adults with obesity or weight-related health conditions. As with all prescription weight loss treatments, it is essential to consult a qualified healthcare professional for individual assessment and safe use.
Summary of Differences Between Prescription Weight Loss Injections
In summary, prescription weight loss injections available in Singapore share a common mechanism of supporting appetite regulation and promoting weight loss through hormonal pathways. However, they differ in terms of their active ingredient, dosing frequency, and primary clinical use.
The daily GLP-1 receptor agonist injection (based on liraglutide and developed by Novo Nordisk) requires once-daily administration and is approved for chronic weight management.
The once-weekly GLP-1 injection (containing semaglutide, also from Novo Nordisk) is primarily used for blood sugar control in type 2 diabetes but can also support weight loss.
The high-dose, once-weekly GLP-1 weight loss pen (a higher dose of semaglutide by Novo Nordisk) is specifically approved for long-term weight management in adults with overweight or obesity.
The dual-action GLP-1/GIP receptor agonist injection (tirzepatide, developed by Eli Lilly) is administered once weekly and targets two key hormonal pathways, offering enhanced weight loss support for individuals with obesity or related health conditions.
Enhanced weight loss for obesity/weight-related health
Each medication has its own suitability profile based on health status, lifestyle, and personal preferences. The best choice should always be made in consultation with your doctor, who can assess your medical history and recommend the most appropriate prescription weight loss injection for your needs.
The Weight Loss Injections Treatment Experience in Singapore
Consultation and Prescription: The treatment journey begins with a medical consultation. Your doctor will assess your overall health, medical history, and individual weight loss goals to determine whether you are a suitable candidate for prescription weight loss injections. If these medications are deemed appropriate, your doctor will prescribe a specific injectable based on your needs and preferences.
Patient Training: Before starting treatment, you will receive practical training on how to self-administer the injections at home. This typically involves learning to inject the medication into the fatty tissue just under the skin—usually in the abdomen or thigh—using a pre-filled pen device. Your healthcare provider will ensure you are comfortable with the technique and confident about safe self-administration.
Dosage and Frequency: The specific dosage and frequency of your weight loss injections will depend on the prescribed medication. Some options are designed for daily use, while others are administered once weekly. Your doctor will advise on the correct starting dose, which is often gradually increased over time to optimise results and minimise side effects.
Ongoing Monitoring: Regular follow-up appointments are an essential part of the treatment process. Your doctor will monitor your progress, assess your response to the medication, and make any necessary adjustments to your dosage. Common side effects—including nausea, diarrhoea, or constipation—may occur in the initial weeks but typically improve as your body adapts to the treatment.
Lifestyle Modifications: Prescription weight loss injections are most effective when combined with a healthy lifestyle. Your doctor will recommend a reduced-calorie diet, increased physical activity, and other positive behaviour changes to maximise your results and support long-term success.
Duration of Treatment: The length of treatment varies for each patient and depends on factors such as your weight loss response, tolerance of the medication, and ongoing health goals. Some individuals may benefit from longer-term use of these injections to maintain their results, always under regular medical supervision.
When Can Weight Loss Injection Results Be Seen?
Timeline for Results The timeframe for noticeable results with prescription weight loss injections can vary from person to person. Many patients may begin to observe some reduction in weight within the first few weeks of starting treatment.
More significant and sustained weight loss is typically seen within the first three to six months, as the body adapts to the medication and responds to changes in appetite and metabolism.
Expected Weight Loss Individual outcomes depend on factors such as starting weight, dietary habits, physical activity level, and adherence to the prescribed regimen. On average, clinical studies have shown that patients using prescription weight loss injections can expect to lose approximately 5% to 15% of their initial body weight over six to twelve months.
Monitoring Progress Regular follow-up appointments with your doctor are essential to monitor your progress and make any necessary adjustments to your treatment plan. Your doctor will assess your weight loss, review any side effects, and provide guidance on lifestyle changes to support long-term success.
If after 12 weeks of consistent use you have not achieved at least 4–5% reduction in your initial body weight, your healthcare provider may recommend discontinuing the medication or exploring alternative weight management options.
Who Is Suitable for Weight Loss Injections in Singapore?
Prescription weight loss injections are generally recommended for adults who have not achieved sufficient weight loss through diet and exercise alone and meet specific medical criteria. You may be suitable for these treatments if:
You have a body mass index (BMI) of 27 kg/m² or higher with weight-related health conditions (such as type 2 diabetes, high blood pressure, or high cholesterol).
You have a BMI of 30 kg/m² or higher, regardless of other health conditions.
You are willing to commit to regular follow-up appointments, dietary changes, and increased physical activity as part of a comprehensive medical weight loss programme.
You do not have contraindications such as a history of pancreatitis, certain thyroid disorders, or allergies to any of the medication’s ingredients.
Eligibility is always determined after a thorough assessment by a qualified doctor. Your healthcare provider will consider your overall medical history, current medications, and weight loss goals before recommending an appropriate treatment plan.
For more information on weight loss injection eligibility, book a consultation with our clinic.
Duration of Treatment: Is It A Lifelong Treatment?
The duration of treatment with prescription weight loss injections depends on your individual health goals, progress, and how your body responds to the medication. For some patients, these injections may be used as a short- or medium-term tool to achieve weight loss, with the possibility of discontinuing treatment once their goals are met and healthy habits are firmly established.
Others may benefit from longer-term use to help maintain their weight loss and ongoing health improvements. This is because obesity is considered a chronic condition, and some individuals may experience a tendency for weight regain after stopping medication. In the STEP 4 clinical trial, researchers found that weight regain could occur after stopping semaglutide, underscoring the importance of ongoing lifestyle changes and follow-up care (NEJM STEP 4 semaglutide withdrawal study).
Importantly, the decision about how long to continue weight loss injections is highly individual. Your doctor will regularly assess your progress, discuss your preferences, and adjust your treatment plan as needed to help you achieve lasting results. With a supportive, holistic approach that includes dietary improvements, regular exercise, and behavioural strategies, many patients can achieve sustainable weight management—regardless of whether medication is used long-term.
Risks of Weight Loss Injections in Singapore
While prescription weight loss injections can be highly effective for supporting weight management, it is important to be aware of their potential side effects. Most patients tolerate these medications well, and serious complications are uncommon, especially when used under medical supervision.
Common Side Effects The most frequently reported side effects of weight loss injections are related to the digestive system. These include nausea, diarrhoea, constipation, and occasional vomiting. Such effects are usually mild and tend to resolve as your body adapts to the medication over time.
Other Side Effects Some patients may experience less common effects such as dizziness, fatigue, a slight increase in heart rate, or reactions at the injection site (such as redness, swelling, or mild discomfort).
Serious Side Effects Rarely, more serious complications may occur. These include pancreatitis (inflammation of the pancreas), gallbladder disease, kidney issues, and—very rarely—mood changes, including suicidal thoughts or behaviours. The overall risk of these events is low, but it is essential to seek immediate medical attention if you develop symptoms such as severe abdominal pain, persistent nausea or vomiting, yellowing of the skin or eyes, reduced urination, or unexplained mood changes.
Weight loss injections are a promising option for medically supervised weight management, but they should always be used as part of a comprehensive treatment plan that includes healthy lifestyle changes. Consultation and ongoing follow-up with a qualified healthcare professional will help ensure the safest and most effective results for your individual needs.
Are Weight Loss Injections Available in Singapore?
Yes, prescription weight loss injections are available in Singapore. Options include daily injections like Saxenda, once-weekly GLP-1 injections such as Ozempic and Wegovy, and dual-action injectables like Zepbound and Mounjaro. All require a doctor’s consultation to assess your suitability and medical needs.
Can I Use Weight Loss Injections Without Having Diabetes?
Yes, certain weight loss injections can be prescribed to individuals without diabetes, depending on their health profile and goals. In Singapore, Ozempic is officially approved for blood sugar control in people with type 2 diabetes, but it may be used off-label for weight loss in selected cases under medical supervision.
Wegovy and Mounjaro are injectable medications specifically developed and approved for long-term weight management in individuals with overweight or obesity—even if they do not have diabetes. Your doctor will assess your eligibility based on your BMI, health history, and weight loss needs before recommending any treatment.
How Often Do I Need to Take Weight Loss Injections?
The dosing schedule depends on the prescribed medication. Saxenda is typically injected once daily, while Ozempic, Wegovy and Mounjaro are administered once weekly. Your doctor will recommend the best option and frequency based on your individual needs.
What Results Can I Expect With Weight Loss Injections?
Most patients start to notice a reduced appetite within the first few weeks of treatment. More significant weight loss is typically seen after three to six months of consistent use. Clinical trials with medications like Wegovy, Ozempic, and Mounjaro have shown average weight loss of 5% to 15% of initial body weight over six to twelve months, especially when combined with a healthy lifestyle.
Are Weight Loss Injections Safe?
When prescribed and monitored by a qualified doctor, weight loss injections such as Saxenda, Wegovy, Ozempic and Mounjaro are generally safe. Common side effects include nausea, gastrointestinal discomfort, or mild injection site reactions. Your doctor will discuss all potential side effects and monitor your progress throughout your treatment.
What Are the Common Side Effects of Weight Loss Injections?
The most frequent side effects are gastrointestinal, such as nausea, diarrhoea, constipation, and sometimes vomiting. Other possible effects include dizziness, fatigue, or mild redness at the injection site. Serious side effects like pancreatitis, gallbladder issues, or mood changes are rare but possible; any concerning symptoms should be reported to your doctor immediately.
Do I Need to Make Lifestyle Changes While on Weight Loss Injections?
Yes, weight loss injections are most effective when paired with a reduced-calorie diet, increased physical activity, and behavioural changes. Programmes using medications like Saxenda, Wegovy, and Mounjaro typically include dietary guidance and lifestyle coaching as part of a comprehensive weight management plan.
Who Is Not Suitable for Weight Loss Injections?
Not everyone is a candidate for GLP-1 or dual agonist injectables. Factors such as personal medical history, BMI, and certain health conditions (like pancreatitis or thyroid disease) may affect eligibility. Your suitability will be determined by your doctor during a comprehensive medical assessment.
How Long Do I Need to Stay on Weight Loss Injections?
The duration of treatment varies. Some patients may use injections like Wegovy or Mounjaro for several months, while others benefit from longer-term use to maintain weight loss. Decisions about continuing or stopping medication should always be made in consultation with your healthcare provider, based on your response and long-term goals.
Do I Need a Medical Consultation Before Starting?
Yes, a medical consultation is required before beginning any weight loss injection therapy in Singapore. This allows your doctor to assess your suitability for treatments such as Saxenda, Ozempic, Wegovy, or Mounjaro, and to develop a safe, personalised treatment plan for you.
What Is the Difference Between GLP-1 and Dual-Action Weight Loss Injections?
GLP-1 injections, such as Saxenda, Ozempic, and Wegovy, work by mimicking the effects of the natural GLP-1 hormone to reduce appetite and regulate blood sugar. Dual-action injectables, like Mounjaro and Zepbound, activate both GLP-1 and GIP receptors, providing a combined approach for enhanced appetite control and metabolic benefits. Your doctor will recommend the most suitable option for your needs.
How Do I Choose the Best Weight Loss Injection for Me?
The choice of weight loss injection depends on individual health status, weight loss goals, and medical history. Your doctor will evaluate factors such as BMI, existing health conditions, medication tolerance, and previous attempts at weight loss before recommending options like Wegovy, Saxenda, Ozempic, or Mounjaro.
Can Weight Loss Injections Improve Blood Sugar and Heart Health?
Yes, several prescription weight loss injections offer benefits beyond just weight reduction. Medications such as Ozempic and Wegovy (semaglutide), as well as Mounjaro (tirzepatide), were originally developed for blood sugar control in people with type 2 diabetes.
These injections help regulate glucose levels by slowing gastric emptying and enhancing insulin response, which can lead to improved blood sugar management—even in people without diabetes.
Additionally, clinical studies have shown that weight loss injections may provide cardiovascular benefits. For example, semaglutide has been associated with a reduced risk of major adverse cardiovascular events in patients with overweight or obesity and existing heart disease.
These medications may help lower blood pressure, improve cholesterol levels, and reduce overall cardiovascular risk when used as part of a comprehensive treatment plan under medical supervision.
How Do I Find the Best Weight Loss Treatment Clinic Singapore Has to Offer?
When choosing a weight loss clinic in Singapore, prioritise those with experienced doctors who specialise in medical weight management. Leading clinics offer a comprehensive range of treatment options, including prescription-based injectables such as GLP-1 and dual-action weight loss injections.
The best clinics take a personalised, doctor-supervised approach. This involves a thorough consultation, tailored treatment planning, ongoing monitoring, and holistic lifestyle support. Transparent communication about the expected outcomes, potential side effects, and overall costs is essential for a safe and effective weight loss journey.
For professional advice and personalised care, book a consultation with our experienced medical team.
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